Key gene discovery for obesity and diabetes

KLF14 is a gene thought to act like a “Master Switch” for controlling other genes in body fat. The MuTHER study is a large multi-national collaboration and used fat biopsies from under the skin or subcutaneous fat samples from 800 female twin subjects and confirmed that KLF14 was controlling distant gene expression levels in other genes found in the fat tissue with 600 samples from a separate group of people. KLF14 controls traits that in turn affect metabolic syndrome, obesity and type 2 diabetes. This finding may help understand the causes of obesity and its related diseases and how